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Web bupropion hydrochloride tablets are a prescription medicine used to treat adults with a certain type of depression called major depressive disorder. This information from lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call. The food and drug administration (fda) approved these atypical antidepressants to treat depression:. Web bupropion is an antidepressant medication used to treat depression and seasonal affective disorder, it also supports smoking cessation and weight management.